Prediction of acute coronary syndromes by urinary proteome analysis
Identifieur interne : 000574 ( Main/Exploration ); précédent : 000573; suivant : 000575Prediction of acute coronary syndromes by urinary proteome analysis
Auteurs : Nay M. Htun [Australie] ; Dianna J. Magliano [Australie] ; Zhen-Yu Zhang [Belgique] ; Jasmine Lyons [Australie] ; Thibault Petit [Belgique] ; Esther Nkuipou-Kenfack [Allemagne] ; Adela Ramirez-Torres [Allemagne, États-Unis] ; Constantin Von Zur Muhlen [Allemagne] ; David Maahs [États-Unis] ; Joost P. Schanstra [France] ; Claudia Pontillo [Allemagne] ; Martin Pejchinovski [Allemagne] ; Janet K. Snell-Bergeon [États-Unis] ; Christian Delles [Royaume-Uni] ; Harald Mischak [Allemagne, Royaume-Uni] ; Jan A. Staessen [Belgique, Pays-Bas] ; Jonathan E. Shaw [Australie] ; Thomas Koeck [Allemagne] ; Karlheinz Peter [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Aire sous la courbe, Analyse de survie, Courbe ROC, Facteurs de l'âge, Facteurs de risque, Femelle, Humains, Machine à vecteur de support, Marqueurs biologiques (urine), Mâle, Peptides (urine), Pronostic, Protéome (analyse), Protéomique, Spectrométrie de masse, Sujet âgé, Syndrome coronarien aigu (diagnostic), Syndrome coronarien aigu (mortalité), Syndrome coronarien aigu (métabolisme), Syndrome coronarien aigu (urine), Électrophorèse capillaire, Études cas-témoins.
- MESH :
- analyse : Protéome.
- diagnostic : Syndrome coronarien aigu.
- mortalité : Syndrome coronarien aigu.
- métabolisme : Syndrome coronarien aigu.
- urine : Adulte d'âge moyen, Aire sous la courbe, Analyse de survie, Courbe ROC, Facteurs de l'âge, Facteurs de risque, Femelle, Humains, Machine à vecteur de support, Marqueurs biologiques, Mâle, Peptides, Pronostic, Protéomique, Spectrométrie de masse, Sujet âgé, Syndrome coronarien aigu, Électrophorèse capillaire, Études cas-témoins.
English descriptors
- KwdEn :
- Acute Coronary Syndrome (diagnosis), Acute Coronary Syndrome (metabolism), Acute Coronary Syndrome (mortality), Acute Coronary Syndrome (urine), Age Factors, Aged, Area Under Curve, Biomarkers (urine), Case-Control Studies, Electrophoresis, Capillary, Female, Humans, Male, Mass Spectrometry, Middle Aged, Peptides (urine), Prognosis, Proteome (analysis), Proteomics, ROC Curve, Risk Factors, Support Vector Machine, Survival Analysis.
- MESH :
- chemical , analysis : Proteome.
- chemical , urine : Biomarkers, Peptides.
- diagnosis : Acute Coronary Syndrome.
- metabolism : Acute Coronary Syndrome.
- mortality : Acute Coronary Syndrome.
- urine : Acute Coronary Syndrome.
- Age Factors, Aged, Area Under Curve, Case-Control Studies, Electrophoresis, Capillary, Female, Humans, Male, Mass Spectrometry, Middle Aged, Prognosis, Proteomics, ROC Curve, Risk Factors, Support Vector Machine, Survival Analysis.
Abstract
Identification of individuals who are at risk of suffering from acute coronary syndromes (ACS) may allow to introduce preventative measures. We aimed to identify ACS-related urinary peptides, that combined as a pattern can be used as prognostic biomarker. Proteomic data of 252 individuals enrolled in four prospective studies from Australia, Europe and North America were analyzed. 126 of these had suffered from ACS within a period of up to 5 years post urine sampling (cases). Proteomic analysis of 84 cases and 84 matched controls resulted in the discovery of 75 ACS-related urinary peptides. Combining these to a peptide pattern, we established a prognostic biomarker named Acute Coronary Syndrome Predictor 75 (ACSP75). ACSP75 demonstrated reasonable prognostic discrimination (c-statistic = 0.664), which was similar to Framingham risk scoring (c-statistics = 0.644) in a validation cohort of 42 cases and 42 controls. However, generating by a composite algorithm named Acute Coronary Syndrome Composite Predictor (ACSCP), combining the biomarker pattern ACSP75 with the previously established urinary proteomic biomarker CAD238 characterizing coronary artery disease as the underlying aetiology, and age as a risk factor, further improved discrimination (c-statistic = 0.751) resulting in an added prognostic value over Framingham risk scoring expressed by an integrated discrimination improvement of 0.273 ± 0.048 (
Url:
DOI: 10.1371/journal.pone.0172036
PubMed: 28273075
PubMed Central: 5342174
Affiliations:
- Allemagne, Australie, Belgique, France, Pays-Bas, Royaume-Uni, États-Unis
- Californie, Colorado, Midi-Pyrénées, Occitanie (région administrative), Victoria (État), Écosse
- Glasgow, Melbourne, Toulouse
- Université de Glasgow
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Le document en format XML
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id="aff008"><addr-line>Department of Paediatrics, Stanford School of Medicine, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Paediatrics, Stanford School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff009"><addr-line>Barbara Davis Centre for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Barbara Davis Centre for Diabetes, University of Colorado School of Medicine, Aurora, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. 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Staessen</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>R&D VitaK Group, Maastricht University, Maastricht, Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>R&D VitaK Group, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Jonathan E" sort="Shaw, Jonathan E" uniqKey="Shaw J" first="Jonathan E." last="Shaw">Jonathan E. Shaw</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Koeck, Thomas" sort="Koeck, Thomas" uniqKey="Koeck T" first="Thomas" last="Koeck">Thomas Koeck</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Mosaiques Diagnostics GmbH, Hanover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mosaiques Diagnostics GmbH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Peter, Karlheinz" sort="Peter, Karlheinz" uniqKey="Peter K" first="Karlheinz" last="Peter">Karlheinz Peter</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medicine, Monash University, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28273075</idno><idno type="pmc">5342174</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342174</idno><idno type="RBID">PMC:5342174</idno><idno type="doi">10.1371/journal.pone.0172036</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002969</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002969</idno><idno type="wicri:Area/Pmc/Curation">002819</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002819</idno><idno type="wicri:Area/Pmc/Checkpoint">000143</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000143</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000F32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F32</idno><idno type="wicri:Area/PubMed/Curation">000F29</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F29</idno><idno type="wicri:Area/PubMed/Checkpoint">000F29</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F29</idno><idno type="wicri:Area/Ncbi/Merge">004434</idno><idno type="wicri:Area/Ncbi/Curation">004434</idno><idno type="wicri:Area/Ncbi/Checkpoint">004434</idno><idno type="wicri:Area/Main/Merge">000569</idno><idno type="wicri:Area/Main/Curation">000574</idno><idno type="wicri:Area/Main/Exploration">000574</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prediction of acute coronary syndromes by urinary proteome analysis</title><author><name sortKey="Htun, Nay M" sort="Htun, Nay M" uniqKey="Htun N" first="Nay M." last="Htun">Nay M. Htun</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medicine, Monash University, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Magliano, Dianna J" sort="Magliano, Dianna J" uniqKey="Magliano D" first="Dianna J." last="Magliano">Dianna J. Magliano</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Zhang, Zhen Yu" sort="Zhang, Zhen Yu" uniqKey="Zhang Z" first="Zhen-Yu" last="Zhang">Zhen-Yu Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Lyons, Jasmine" sort="Lyons, Jasmine" uniqKey="Lyons J" first="Jasmine" last="Lyons">Jasmine Lyons</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Petit, Thibault" sort="Petit, Thibault" uniqKey="Petit T" first="Thibault" last="Petit">Thibault Petit</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Nkuipou Kenfack, Esther" sort="Nkuipou Kenfack, Esther" uniqKey="Nkuipou Kenfack E" first="Esther" last="Nkuipou-Kenfack">Esther Nkuipou-Kenfack</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Mosaiques Diagnostics GmbH, Hanover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mosaiques Diagnostics GmbH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Ramirez Torres, Adela" sort="Ramirez Torres, Adela" uniqKey="Ramirez Torres A" first="Adela" last="Ramirez-Torres">Adela Ramirez-Torres</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Mosaiques Diagnostics GmbH, Hanover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mosaiques Diagnostics GmbH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Von Zur Muhlen, Constantin" sort="Von Zur Muhlen, Constantin" uniqKey="Von Zur Muhlen C" first="Constantin" last="Von Zur Muhlen">Constantin Von Zur Muhlen</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Department of Cardiology, University Heart Centre Freiburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, University Heart Centre Freiburg</wicri:regionArea><wicri:noRegion>University Heart Centre Freiburg</wicri:noRegion><wicri:noRegion>University Heart Centre Freiburg</wicri:noRegion><wicri:noRegion>University Heart Centre Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Maahs, David" sort="Maahs, David" uniqKey="Maahs D" first="David" last="Maahs">David Maahs</name><affiliation wicri:level="2"><nlm:aff id="aff008"><addr-line>Department of Paediatrics, Stanford School of Medicine, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Paediatrics, Stanford School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff009"><addr-line>Barbara Davis Centre for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Barbara Davis Centre for Diabetes, University of Colorado School of Medicine, Aurora, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. Schanstra</name><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff011"><addr-line>Université Toulouse III Paul-Sabatier, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Toulouse III Paul-Sabatier, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Pontillo, Claudia" sort="Pontillo, Claudia" uniqKey="Pontillo C" first="Claudia" last="Pontillo">Claudia Pontillo</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Mosaiques Diagnostics GmbH, Hanover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mosaiques Diagnostics GmbH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Pejchinovski, Martin" sort="Pejchinovski, Martin" uniqKey="Pejchinovski M" first="Martin" last="Pejchinovski">Martin Pejchinovski</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Mosaiques Diagnostics GmbH, Hanover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mosaiques Diagnostics GmbH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Snell Bergeon, Janet K" sort="Snell Bergeon, Janet K" uniqKey="Snell Bergeon J" first="Janet K." last="Snell-Bergeon">Janet K. Snell-Bergeon</name><affiliation wicri:level="2"><nlm:aff id="aff009"><addr-line>Barbara Davis Centre for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Barbara Davis Centre for Diabetes, University of Colorado School of Medicine, Aurora, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Delles, Christian" sort="Delles, Christian" uniqKey="Delles C" first="Christian" last="Delles">Christian Delles</name><affiliation wicri:level="4"><nlm:aff id="aff012"><addr-line>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Mischak, Harald" sort="Mischak, Harald" uniqKey="Mischak H" first="Harald" last="Mischak">Harald Mischak</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Mosaiques Diagnostics GmbH, Hanover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mosaiques Diagnostics GmbH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff012"><addr-line>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>R&D VitaK Group, Maastricht University, Maastricht, Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>R&D VitaK Group, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Jonathan E" sort="Shaw, Jonathan E" uniqKey="Shaw J" first="Jonathan E." last="Shaw">Jonathan E. Shaw</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Koeck, Thomas" sort="Koeck, Thomas" uniqKey="Koeck T" first="Thomas" last="Koeck">Thomas Koeck</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Mosaiques Diagnostics GmbH, Hanover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mosaiques Diagnostics GmbH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Peter, Karlheinz" sort="Peter, Karlheinz" uniqKey="Peter K" first="Karlheinz" last="Peter">Karlheinz Peter</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medicine, Monash University, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Coronary Syndrome (diagnosis)</term><term>Acute Coronary Syndrome (metabolism)</term><term>Acute Coronary Syndrome (mortality)</term><term>Acute Coronary Syndrome (urine)</term><term>Age Factors</term><term>Aged</term><term>Area Under Curve</term><term>Biomarkers (urine)</term><term>Case-Control Studies</term><term>Electrophoresis, Capillary</term><term>Female</term><term>Humans</term><term>Male</term><term>Mass Spectrometry</term><term>Middle Aged</term><term>Peptides (urine)</term><term>Prognosis</term><term>Proteome (analysis)</term><term>Proteomics</term><term>ROC Curve</term><term>Risk Factors</term><term>Support Vector Machine</term><term>Survival Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Aire sous la courbe</term><term>Analyse de survie</term><term>Courbe ROC</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Machine à vecteur de support</term><term>Marqueurs biologiques (urine)</term><term>Mâle</term><term>Peptides (urine)</term><term>Pronostic</term><term>Protéome (analyse)</term><term>Protéomique</term><term>Spectrométrie de masse</term><term>Sujet âgé</term><term>Syndrome coronarien aigu (diagnostic)</term><term>Syndrome coronarien aigu (mortalité)</term><term>Syndrome coronarien aigu (métabolisme)</term><term>Syndrome coronarien aigu (urine)</term><term>Électrophorèse capillaire</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Proteome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Biomarkers</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Acute Coronary Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome coronarien aigu</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acute Coronary Syndrome</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Acute Coronary Syndrome</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Syndrome coronarien aigu</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Syndrome coronarien aigu</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Acute Coronary Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Area Under Curve</term><term>Case-Control Studies</term><term>Electrophoresis, Capillary</term><term>Female</term><term>Humans</term><term>Male</term><term>Mass Spectrometry</term><term>Middle Aged</term><term>Prognosis</term><term>Proteomics</term><term>ROC Curve</term><term>Risk Factors</term><term>Support Vector Machine</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Aire sous la courbe</term><term>Analyse de survie</term><term>Courbe ROC</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Machine à vecteur de support</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Peptides</term><term>Pronostic</term><term>Protéomique</term><term>Spectrométrie de masse</term><term>Sujet âgé</term><term>Syndrome coronarien aigu</term><term>Électrophorèse capillaire</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Identification of individuals who are at risk of suffering from acute coronary syndromes (ACS) may allow to introduce preventative measures. We aimed to identify ACS-related urinary peptides, that combined as a pattern can be used as prognostic biomarker. Proteomic data of 252 individuals enrolled in four prospective studies from Australia, Europe and North America were analyzed. 126 of these had suffered from ACS within a period of up to 5 years post urine sampling (cases). Proteomic analysis of 84 cases and 84 matched controls resulted in the discovery of 75 ACS-related urinary peptides. Combining these to a peptide pattern, we established a prognostic biomarker named Acute Coronary Syndrome Predictor 75 (ACSP75). ACSP75 demonstrated reasonable prognostic discrimination (c-statistic = 0.664), which was similar to Framingham risk scoring (c-statistics = 0.644) in a validation cohort of 42 cases and 42 controls. However, generating by a composite algorithm named Acute Coronary Syndrome Composite Predictor (ACSCP), combining the biomarker pattern ACSP75 with the previously established urinary proteomic biomarker CAD238 characterizing coronary artery disease as the underlying aetiology, and age as a risk factor, further improved discrimination (c-statistic = 0.751) resulting in an added prognostic value over Framingham risk scoring expressed by an integrated discrimination improvement of 0.273 ± 0.048 (<italic>P</italic> < 0.0001) and net reclassification improvement of 0.405 ± 0.113 (<italic>P</italic> = 0.0007). In conclusion, we demonstrate that urinary peptide biomarkers have the potential to predict future ACS events in asymptomatic patients. 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Htun</name></region><name sortKey="Htun, Nay M" sort="Htun, Nay M" uniqKey="Htun N" first="Nay M." last="Htun">Nay M. Htun</name><name sortKey="Lyons, Jasmine" sort="Lyons, Jasmine" uniqKey="Lyons J" first="Jasmine" last="Lyons">Jasmine Lyons</name><name sortKey="Magliano, Dianna J" sort="Magliano, Dianna J" uniqKey="Magliano D" first="Dianna J." last="Magliano">Dianna J. Magliano</name><name sortKey="Peter, Karlheinz" sort="Peter, Karlheinz" uniqKey="Peter K" first="Karlheinz" last="Peter">Karlheinz Peter</name><name sortKey="Peter, Karlheinz" sort="Peter, Karlheinz" uniqKey="Peter K" first="Karlheinz" last="Peter">Karlheinz Peter</name><name sortKey="Shaw, Jonathan E" sort="Shaw, Jonathan E" uniqKey="Shaw J" first="Jonathan E." last="Shaw">Jonathan E. Shaw</name></country><country name="Belgique"><noRegion><name sortKey="Zhang, Zhen Yu" sort="Zhang, Zhen Yu" uniqKey="Zhang Z" first="Zhen-Yu" last="Zhang">Zhen-Yu Zhang</name></noRegion><name sortKey="Petit, Thibault" sort="Petit, Thibault" uniqKey="Petit T" first="Thibault" last="Petit">Thibault Petit</name><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name></country><country name="Allemagne"><noRegion><name sortKey="Nkuipou Kenfack, Esther" sort="Nkuipou Kenfack, Esther" uniqKey="Nkuipou Kenfack E" first="Esther" last="Nkuipou-Kenfack">Esther Nkuipou-Kenfack</name></noRegion><name sortKey="Koeck, Thomas" sort="Koeck, Thomas" uniqKey="Koeck T" first="Thomas" last="Koeck">Thomas Koeck</name><name sortKey="Mischak, Harald" sort="Mischak, Harald" uniqKey="Mischak H" first="Harald" last="Mischak">Harald Mischak</name><name sortKey="Pejchinovski, Martin" sort="Pejchinovski, Martin" uniqKey="Pejchinovski M" first="Martin" last="Pejchinovski">Martin Pejchinovski</name><name sortKey="Pontillo, Claudia" sort="Pontillo, Claudia" uniqKey="Pontillo C" first="Claudia" last="Pontillo">Claudia Pontillo</name><name sortKey="Ramirez Torres, Adela" sort="Ramirez Torres, Adela" uniqKey="Ramirez Torres A" first="Adela" last="Ramirez-Torres">Adela Ramirez-Torres</name><name sortKey="Von Zur Muhlen, Constantin" sort="Von Zur Muhlen, Constantin" uniqKey="Von Zur Muhlen C" first="Constantin" last="Von Zur Muhlen">Constantin Von Zur Muhlen</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Ramirez Torres, Adela" sort="Ramirez Torres, Adela" uniqKey="Ramirez Torres A" first="Adela" last="Ramirez-Torres">Adela Ramirez-Torres</name></region><name sortKey="Maahs, David" sort="Maahs, David" uniqKey="Maahs D" first="David" last="Maahs">David Maahs</name><name sortKey="Maahs, David" sort="Maahs, David" uniqKey="Maahs D" first="David" last="Maahs">David Maahs</name><name sortKey="Snell Bergeon, Janet K" sort="Snell Bergeon, Janet K" uniqKey="Snell Bergeon J" first="Janet K." last="Snell-Bergeon">Janet K. Snell-Bergeon</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. Schanstra</name></region><name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. Schanstra</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Delles, Christian" sort="Delles, Christian" uniqKey="Delles C" first="Christian" last="Delles">Christian Delles</name></region><name sortKey="Mischak, Harald" sort="Mischak, Harald" uniqKey="Mischak H" first="Harald" last="Mischak">Harald Mischak</name></country><country name="Pays-Bas"><noRegion><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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